Diverse Toxic Chemicals Disrupt Cell Function through a Common Path

Diverse Toxic Chemicals Disrupt Cell Function through a Common Path

0001 When technological advances in the 1930s provided the means to synthesize chemicals from petroleum and natural gas, the petrochemical industry ramped up production of diverse species of novel compounds without testing their safety. By 1940, a billion pounds of synthetic petrochemicals were produced each year. Of the more than 38 million chemicals reported in the scientifi c literature, 80,...

Chemically Diverse Toxicants Converge on Fyn and c-Cbl to Disrupt Precursor Cell Function

Identification of common mechanistic principles that shed light on the action of the many chemically diverse toxicants to which we are exposed is of central importance in understanding how toxicants disrupt normal cellular function and in developing more effective means of protecting against such effects. Of particular importance is identifying mechanisms operative at environmentally relevant t...

Pesticides and toxic chemicals

‘Contamination’ is a comparative term. In Britain at least, contaminants are trace substances; in the context of food they are distinguished from additives by whether or not there is an intention that the substances should be present when the food is consumed or prepared for consumption. Contaminants may be of natural or of technological origin: and technological contaminants may be direct or i...

ToxiC inhalaTional injury and ToxiC indusTrial ChemiCals

Pesticides and toxic chemicals.

‘Contamination’ is a comparative term. In Britain at least, contaminants are trace substances; in the context of food they are distinguished from additives by whether or not there is an intention that the substances should be present when the food is consumed or prepared for consumption. Contaminants may be of natural or of technological origin: and technological contaminants may be direct or i...